Banri Tada is a freshman at a Tokyo law school. After an accident, he suffers severe memory loss. Despite the incident, he befriends fellow freshman, Mitsuo Yanagisawa, which leads him to the beautiful, yet obsessive, Kouko Kaga.
Anime is not just about giant robots and martial arts--there are many series with hilarious comedic undertones, they're not sit-coms to be sure, but you'll find yourself laughing between samurai battles.
Many anime series are targeted at teens, so it's not surprising that many are set in high schools--this list rounds them up with a few series set in middle school or the early college years for good measure.