When a cockroach-spread plague threatened to decimate the child population of New York City in the original Mimic, biologist Susan Tyler and her research associates developed a crossbreed species of insect, the "Judas Breed" and introduced them into the environment, where they were to spread a toxin, lethal to the cockroaches.
A man is taken to a small clinic in Guam with mysterious bites on him. This sparks a search for what could have caused such wounds. A group of men and women fly to the island he lived on to investigate the situation. Due to technical problems, their small plane crashes and they are stranded on the island.
A DNA experiment on a rare breed of spider is taking place on a NASA space shuttle, when a freak meteor shower engulfs the shuttle, causing everything to go horribly wrong. One survivor is found on the ship and watched over in a secret location deep in the California desert. The problem continues, as the survivor isn't alone, as another deadly spiders climbs out of him and goes on a rampage around the ship. Curious reporter Marci Eyre must now survive, escape and warn everyone before the spider reaches outside the desert.
In India, the backpacker American friends Gina, John, Stacy, Geraldine and Phil hike in the woods with their guide Brian. When Geraldine is bitten by a poisonous spider, the group decides to seek an American doctor that lives in the jungle in a tribe. Dr. Lecorpus treats the girl and while Gina, John and Phil return to the village in the civilization, Brian and Stacy stay with the native.
When a young ski team training for the Olympics arrives at the remote and isolated Lost Mountain Ski Resort to focus on training, they're thrilled to find a retired Olympic skier is there to help them train. But their plans are halted when a scientist working at a nearby government lab arrives with the horrifying news that a top secret Government project has produced giant spiders and they have escaped, killing and eating everything in sight.