Hazel and Gus are two teenagers who share an acerbic wit, a disdain for the conventional, and a love that sweeps them on a journey. Their relationship is all the more miraculous given that Hazel's other constant companion is an oxygen tank, Gus jokes about his prosthetic leg, and they met and fell in love at a cancer support group.
Depressed single mom Adele and her son Henry offer a wounded, fearsome man a ride. As police search town for the escaped convict, the mother and son gradually learn his true story as their options become increasingly limited.
After Davey's father is killed in a hold-up, she and her mother and younger brother visit relatives in New Mexico. Here Davey is befriended by a young man who helps her find the strength to carry on and conquer her fears.